Interested in Applying for Research Funds?

Grant applications due:  October 1, 2017

Decision date:   No later than January 15, 2018

Funding begins: upon signed grant agreement.

In addition to scientific studies, PAF is looking for clinical studies on complications of propionic acidemia including:

  • Cardiomyopathy
  • Long QT
  • Hyperammonemia
  • Neutropenia
  • Pancreatitis
  • Secondary immune deficiency
  • Treatment
  • Gut microbial flora control
  • Gastrointestinal motility

We encourage all investigators working towards a cure or better treatments for propionic acidemia to contact the Propionic Acidemia Foundation for possible funding.

Format for PAF Research Funding Proposals

Section I – General Information
Section II – Research Plan
Section III – Budget


PAF Grant Type
Indicate whether you are applying for an initial PAF research grant or for a PAF continuation studies grant. Continuation studies grant applicants must include a Progress Report* in Section II of the application.

Description and Personnel
Describe briefly the overall research program, indicate the emphasis of the component research projects, and identify the purpose of each proposed area of study. List the key scientific and technical personnel participating in the program.

Biographical Sketch
Biographical sketches are required for all key scientific and technical personnel participating in the research projects. Submit biographical sketches containing essential information describing the qualifications of all key research personnel.

Briefly describe the features of the institutional environment that are or would be relevant to the effective implementation of the proposed program. As appropriate, describe available resources, such as clinical and laboratory facilities, participating and affiliated units, patient or laboratory animal populations, geographical distribution of space and personnel, and consultative resources.


Research Project Description
Each research project within the proposed program of study should include the following identifying information:

  • Project Title
  • Project number (I,II,III etc.)
  • Project Principal Investigator, title, location
  • Other investigators, consultants, and collaborators, titles (Associate Professor, Postdoctoral Fellow, student).

Research Project Plan
Provide detailed information about each project by addressing the following:

  1. Specific Aims/Objectives
  2. Significance to PA patients
  3. Preliminary Studies if applicable (for continuation grant applications see
    Progress Report* below)
  4. Research Design. Indicate methods, hypotheses, experimental procedures and protocols to be used.
  5. Use of Human Subjects. This section must address the use of children as research subjects if applicable.
  6. Use of Vertebrate Animals

Show a proposed timeline for individual research projects to be implemented.

Progress Report
For continuation grant applications a progress report should be included. Include pertinent data obtained during the current grant period.

List relevant publications prepared during the past five-year period. For continuation applications, list research articles submitted during the current grant period whether published or in press.

Assurances and Collaborative Agreements
Any arrangements for collaborative and cooperative endeavors or subcontracting should be highlighted. Letters of Intent to Collaborate and Letters of Agreement from consultants should be referenced here.


Budget Estimates
A detailed budget for each research project should be submitted. Present the total direct cost estimate for all categories of requested support. Indirect costs will not be payable through the grant.   For each category, such as “PERSONNEL,” “EQUIPMENT,” etc., list the amount requested per each research project for the:

  1. First year
  2. Total proposed project period if longer than 1 year in scope.

Budget Justifications
Describe the specific functions of key scientific and technical personnel including percentage of effort of each study member, consultants, collaborators and support staff participating in each project.

Summary of Other Support
Information regarding active and pending research support of all key scientific and technical personnel should be indicated. Identify other support for the proposed project(s) in the following categories: Current Active Support; and Applications Pending Review or Funding. List each current grant for support of this research. If there are no other grants, indicate “none.”


All PAF Research Funding Proposals will be reviewed by the PAF Medical Advisory Board and by the PAF Board of Directors. Review queries and comments will be addressed to applicants prior to funding by PAF.

Number of awards each cycle is dependent on the number of applications, outcome of review and the availability of funds. PAF is not obligated to make awards following each grant cycle.

If you have any additional questions regarding applications and funding regulations, please email